Analysis of sterilization process for cosmetic packaging

In view of the defects in the field of sterilization and disinfection of cosmetic packaging bottles in China's cosmetics industry for many years, the "JZCF-B" series of ozone disinfection systems for packaging containers are designed and manufactured with obvious disinfection effects by drawing on the international advanced disinfection industry and following the requirements of the "GMP Verification Guidelines" and "Disinfection Technical Specifications" formulated by the Ministry of Health. Cosmetic packaging containers require advanced sterilization process analysis;

1. The principle of ozone sterilization

The sterilization of ozone belongs to the biochemical oxidation reaction. Ozone oxidation breaks down enzymes necessary for the oxidation of glucose inside bacteria; It can also directly interact with bacteria and viruses to destroy their cell walls and ribonucleic acids, decompose macromolecular polymers such as DNA, RNA, proteins, lipids and polysaccharides, and destroy the metabolic growth and reproduction process of bacteria; It can also penetrate the cell membrane tissue, invade the cell membrane and act on the outer membrane lipoprotein and the internal lipopolysaccharide, so that the cell undergoes permeability aberration, resulting in the lysis and death of the cell, and the genetic genes, parasitic strains, parasitic virions, bacteriophages, mycoplasma and pyrogens (bacterial and viral metabolites, endotoxins) in the dead bacteria are dissolved and denatured. The principle of aseptic technology on microorganisms can be divided into three types: bacteriostatic, bactericidal and bacteriolytic, and the use of ozone as a sterilant belongs to bacteriolysis.

In the "Disinfection Technical Specification" promulgated by the Ministry of Health in 1991, there is also a paragraph on the principle of ozone sterilization:

"Scientific studies have shown that ozone has a very strong bactericidal effect." "Ozone is unstable in molecular structure at room temperature and pressure, and quickly decomposes itself into oxygen (O2) and a single oxygen atom (O), the latter of which is highly active and has a strong oxidizing effect on bacteria. Ozone oxidation breaks down the enzymes necessary for the oxidation of glucose inside the bacteria, thereby destroying the cell membrane and killing it, and the excess oxygen atoms will recombine themselves into ordinary oxygen molecules (O2) without any toxic residues, so it is called 'non-polluting disinfectant'. It not only has a strong ability to kill all kinds of bacteria (including hepatitis virus, Escherichia coli, Bacillus aeruginosa and miscellaneous bacteria, etc.), but also is very effective in killing mold. ”